[Term]
id: PR:000000001
name: protein
def: "An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof." [PRO:DAN, PRO:WCB]
comment:  Note that the definition allows for experimentally-manipulated genes, and allows for artifically-produced derivatives that mimic those found naturally. Note also that the definition excludes protein complexes, which some also consider a protein. Those who wish to refer to a class representing both senses of the word are directed to PR:000064867 ("protein-containing molecular entity"). Proteins (in the sense defined here) that descended from a common ancestor can be classified into families and superfamilies composed of products of evolutionarily-related genes. The domain architecture of a protein is described by the order of its constituent domains. Proteins with the same domains in the same order are defined as homeomorphic [PRO:WCB).
synonym: "natural protein" EXACT [PRO:DAN]
synonym: "native protein" NARROW [IEDB:BP]
intersection_of: PR:000018263 ! amino acid chain
intersection_of: output_of GO:0006412 ! translation
intersection_of: has_gene_template SO:0000704 ! gene
relationship: has_part PR:000000001 ! protein