[Term]
id: PR:000000020
name: Myc protein
def: "A protein that belongs to the clade B of the bHLH proteins (see PMID:20219281) with a core domain composition consisting of a Myc amino-terminal region (Pfam:PF01056) regulatory domain (known as TAD domain), a helix-loop-helix DNA-binding domain (Pfam:PF00010). Some members such as c-Myc contains an addition C-terminal Myc leucine zipper domain (Pfam:PF02344). Myc proteins participate in the regulation of cell proliferation, cell differentiation, and apoptosis." [PRO:CNA, PMID:16113099, PMID:16537894, PMID:16543245]
comment: Category=family.
synonym: "bHLH clade B" BROAD [PMID:20219281]
synonym: "bHLH class III" BROAD [PMID:8018712]
xref: PIRSF:PIRSF001705
is_a: PR:000000001 ! protein