[Term]
id: PR:000000046
name: TGF-beta
def: "A TGF-beta-like cystine-knot cytokine whose propeptide region is a latent associated peptide (LAP) that remains associated to the mature TGF-beta after cleavage and secretion, keeping TGF-beta inactive. TGF-beta is the founding member of the cystine-knot cytokine family, and is related to the activin/inhibin, anti-Muellerian hormone, and bone morphogenic protein families, which are all involved in the regulation of cell growth and differentiation." [PIRSF:PIRSF001787]
comment: Category=family.
synonym: "transforming growth factor beta" EXACT []
xref: PIRSF:PIRSF001787
is_a: PR:000000008 ! TGF-beta-like cystine-knot cytokine