[Term]
id: PR:000000659
name: smad3 isoform 1 phosphorylated 2
def: "A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PRO:CNA, PRO:DAN, PMID:15241418]
comment: Category=modification.
synonym: "SMAD3/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000578 ! smad3 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine