[Term]
id: PR:000000660
name: smad3 isoform 1 phosphorylated 3
def: "A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in oncogenic Ras-activated pathway. Example: UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PRO:CNA, PRO:DAN, PMID:10197981]
comment: Category=modification. Note: TGF-receptor phosphorylation sites are not required for Ras-induced phosphorylation.
synonym: "SMAD3/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000578 ! smad3 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine