[Term]
id: PR:000000677
name: shab-related voltage-gated potassium channel alpha subunit
def: "A voltage-gated potassium channel protein that has a conserved carboxyl-terminal domain called the Kv2 channel domain. Kv2 channels are known as delayed rectifier channels. Shab-related voltage-potassium channels are involved in maintaining membrane potential and modulating electrical excitability in neurons. In common with other voltage-gated channels, has a domain composition consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane. The charged S4 segment with a basic amino acid at every third position confers their voltage sensitivity. In common with Kv3 and Kv4 channels, the tetramerization domain at the N terminus contains a zinc binding site." [PRO:CNA]
comment: Category=family.
synonym: "fam:Kchan_shab_sub-a" EXACT PRO-short-label [PRO:DAN]
synonym: "Kv2 channel" RELATED []
xref: PIRSF:PIRSF038520
is_a: PR:000044654 ! voltage-gated potassium channel protein