[Term]
id: PR:000000682
name: voltage-gated potassium channel alpha subunit with PAS domain
def: "A voltage-gated potassium channel protein that has amino- and carboxyl-terminal intracellular domains separated by a domain (common with other ion channels) containing six transmembrane helices (S1-S6) in which the last two helices (S5 and S6) flank a loop, called the pore loop, which determines ion selectivity. Unique to this class is the presence of an N-terminal PAS fold domain (Pfam:PF00989). In addition, in the cytoplasmic region downstream from S6, there is a segment that shares substantial similarity to the Cyclic nucleotide-binding domain (Pfam:PF00027) (CNBD) present in cyclic nucleotide-gated cation channel subunits (PR:000000674 and PR:000000674). These channels regulate membrane excitability." [PMID:8159766]
comment: Category=family.
synonym: "fam:Kchan_sub-a_PAS" EXACT PRO-short-label [PRO:DAN]
xref: PIRSF:PIRSF038287
is_a: PR:000044654 ! voltage-gated potassium channel protein