[Term]
id: PR:000000700
name: intermediate conductance calcium-activated potassium channel protein 4
def: "A calcium-activated calmodulin-binding potassium channel alpha subunit that is a translation product of the human KCNN4 gene or a 1:1 ortholog thereof. It forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. This feature distinguishes the intermediate from the small conductance channels." [PMID:9326665, PMID:9407042]
comment: Category=gene.
synonym: "KCNN4" EXACT PRO-short-label [PRO:DNx]
synonym: "IKCa1" EXACT []
synonym: "KCa3.1" EXACT []
synonym: "KCa4" EXACT []
synonym: "putative Gardos channel" EXACT []
synonym: "SKCa 4" EXACT []
synonym: "SKCa4" EXACT []
synonym: "IK1" RELATED Gene-based []
synonym: "IKCA1" RELATED Gene-based []
synonym: "KCA4" RELATED Gene-based []
synonym: "SK4" RELATED Gene-based []
xref: IUPHARobj:384
property_value: has_archetype PR:O15554
is_a: PR:000000668 ! calcium-activated calmodulin-binding potassium channel alpha subunit