[Term]
id: PR:000000981
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 1
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB). Example: UniProtKB:Q00194-1, Tyr-498, MOD:00048." [PMID:10366613, PMID:14602825]
comment: Category=modification. Note: This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time decreases the apparent affinity for cGMP.
synonym: "CNGA1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000932 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine