[Term]
id: PR:000001094
name: rhodopsin-like G-protein coupled receptor
def: "A G-protein coupled receptor that contains the 7 transmembrane receptor (rhodopsin family) domain (Pfam:PF00001), which includes 7 transmembrane helices (TMI-TM7) with 3 intracellular loops (IL1-IL3) and 3 extracellular loops (EL1-EL3) between the helices. The amino-terminal region is extracellular and the carboxyl-terminal region is intracellular. Rhodopsin-like G-protein coupled receptors (GPCRs) are unique among the several classes of GPCRs in that most have a very short amino-terminal segment and several characteristic sequence motifs, particularly NSxxNPxxY in TM7 and D/E-R-Y/F between TM3 and loop IL2. Most bind their ligands within a cavity between the TM regions." [PRO:DAN, PRO:WCB, PMID:12761335]
comment: Category=family. Classification based on GRAFS system. [PMID:12761335]
synonym: "fam:rhodopsin" EXACT PRO-short-label [PRO:DAN]
synonym: "class 1 G-protein coupled receptor" EXACT [PMID:15914470]
synonym: "class A G-protein coupled receptor" EXACT [IUPHAR:GPCRListForward?class=A]
xref: IUPHAR:GPCRListForward?class=A
xref: PIRSF:PIRSF800006
is_a: PR:000030035 ! G-protein coupled receptor