[Term]
id: PR:000001659
name: prostaglandin E2 receptor EP3 subtype
def: "A prostanoid receptor that is a translation product of the human PTGER3 gene or a 1:1 ortholog thereof. The preferred ligand is prostaglandin E2 (PGE2). This receptor is the most ubiquitous of the prostaglandin E2 receptors, mediating contraction of gastrointestinal, uterine, and vascular smooth muscle, inhibition of neurotransmitter release from autonomic nerves, inhibition of lipolysis in adipocytes, inhibition of acid secretion from gastric mucosa, and inhibition of water reabsorption in kidney." [PRO:WCB, PMID:7938166]
comment: Category=gene.
synonym: "PTGER3" EXACT PRO-short-label [PRO:DNx]
synonym: "PGE receptor EP3 subtype" EXACT []
synonym: "PGE2 receptor EP3 subtype" EXACT []
synonym: "PGE2-R" EXACT []
synonym: "prostaglandin E2 receptor EP3" EXACT []
synonym: "prostanoid EP3 receptor" EXACT []
synonym: "Ptgerep3" RELATED Gene-based []
xref: IUPHARobj:342
property_value: has_archetype PR:P43115
is_a: PR:000001549 ! prostanoid receptor