[Term]
id: PR:000001821
name: MHC class II histocompatibility antigen beta chain
def: "A protein with core architecture consisting of a signal sequence, a Class II histocompatibility antigen, beta domain (Pfam:PF00969) and an Immunoglobulin C1-set domain (Pfam:PF07654); these form the extracellular domain and are followed by a single-pass transmembrane region and a small cytoplasmic region. There are three major and two minor class II MHC (major histocompatability complex) beta chain genes in human. Designations for the MHC complex loci are species specific: HLA (human leukocyte antigen) in human, H-2 in mouse. MHC class II loci are characterized by large numbers of allelic variants." [PRO:WCB, Wikipedia:Human_leukocyte_antigen]
comment: Category=family.
synonym: "MHCcIIbeta" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000000001 ! protein