[Term]
id: PR:000002197
name: caspase-8-like protease
def: "A protein that is a translation product of the human CASP8, CASP10, or CFLAR genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The core domain architecture consists of two consecutive copies of the Death effector domain (DED) domain (Pfam:PF01335) in an amino-terminal propeptide followed by Peptidase_C14 domain (Pfam:PF00656). Encoded as zymogens, the activated proteins are cysteine proteases typically involved in apoptosis." [PRO:DAN, PRO:WCB]
comment: Category=family.
xref: PIRSF:PIRSF037643
is_a: PR:000000001 ! protein