[Term]
id: PR:000002309
name: caspase-1
def: "A caspase-1-like protease that is a translation product of the human CASP1 gene or a 1:1 ortholog thereof. The active form of this protein proteolytically cleaves pro-IL-1beta to its mature, active form. The holoenzyme is a homodimer of catalytic domains, each of which contains the cleaved products caspase-1 p20 and p10 subunits." [PRO:WCB, PMID:8044845]
comment: Category=gene.
synonym: "CASP1" EXACT PRO-short-label [PRO:DNx]
synonym: "CASP-1" EXACT []
synonym: "ICE" EXACT []
synonym: "IL-1 beta-converting enzyme" EXACT []
synonym: "IL-1BC" EXACT []
synonym: "interleukin-1 beta convertase" EXACT []
synonym: "interleukin-1 beta-converting enzyme" EXACT []
synonym: "IL1BC" RELATED Gene-based []
synonym: "IL1BCE" RELATED Gene-based []
synonym: "p45" BROAD [PRO:DNx]
xref: IUPHARobj:1617
property_value: has_archetype PR:P29466
is_a: PR:000002195 ! caspase-1-like protease