[Term]
id: PR:000003290
name: ubiquitin-conjugating enzyme variant
def: "A protein that contains a central Ubiquitin-conjugating enzyme (Pfam:PF00179) domain that has significant similarity to true ubiquitin-conjugating enzymes (Ubcs). However, unlike typical Ubcs, this class lacks the essential Cys residue and hence the catalytic activity required to form a thiol-ester with ubiquitin in the second step of ubiquitination." [PMID:11406273, PMID:9705497]
comment: Category=family.
synonym: "UEV" EXACT []
is_a: PR:000000001 ! protein