[Term]
id: PR:000021977
name: interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated 3
def: "An interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form in which the phosphorylation by interleukin-1 receptor-associated kinase 4 (IRAK-4) occurs on the conserved Thr residue (Thr-209 in human) located near the N terminus of the kinase domain, and on a Thr residue located in the activation loop (Thr-387 in human). The latter phosphorylation is the second step following the activation of the TLR/IL-1 receptor complex. Example: UniProtKB:P51617-1, Thr-209/Thr-387, MOD:00047." [PRO:CNA, PRO:DAN, PMID:14625308]
comment: Category=modification.
synonym: "IRAK1/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "interleukin-1 receptor-associated kinase 1 active" EXACT []
synonym: "pp-IRAK1" EXACT []
is_a: PR:000021971 ! interleukin-1 receptor-associated kinase 1 isoform 1 phosphorylated form
relationship: has_part MOD:00047 ! O-phospho-L-threonine