[Term]
id: PR:000026192
name: neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
def: "A neural cell adhesion molecule L1 isoform 1 that has been phosphorylated on the tyrosine residue of the tyrosine based sorting motif. The tyrosine based sorting motif (YRSLE) in L1CD is required for clathrin mediated endocytosis. Y1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. Example: UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PRO:CNA, PMID:12082080]
comment: Category=modification.
synonym: "L1CAM/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DAN]
is_a: PR:000026190 ! neural cell adhesion molecule L1 isoform 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine