[Term]
id: PR:000026222
name: neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 (human)
def: "A neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1 in human. Tyr-1176 of the YRSLE motif is phosphorylated by SRC tyrosine kinase associated with lipid rafts in the P-domain of the growth cone. Phosphorylation of Y1176 prevents L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1. UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048." [PRO:CNA, PMID:12082080]
comment: Category=organism-modification.
synonym: "hL1CAM/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DAN]
synonym: "PRO_0000015022, Tyr-1176, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P32004-1, 20-1257, Tyr-1176, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-444985 "PR:000026222 located_in GO:0005886"
intersection_of: PR:000026192 ! neural cell adhesion molecule L1 isoform 1, signal peptide removed phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine