[Term]
id: PR:000027192
name: pIRAK4:MYD88:TIRAP:activated TLR4 complex (human)
def: "An IRAK4:MYD88:TIRAP:activated TLR4 complex in human that is composed of activated TLR4 receptor, MyD88, Tirap/Mal, and phosphorylated IRAK4." [PRO:CNA, PMID:17141195]
comment: Category=organism-complex.
synonym: "pIRAK4:MyD88:Mal:activated TLR4 (human)" EXACT [Reactome:R-HSA-937048]
is_a: PR:000027182 ! IRAK4:MYD88:TIRAP:activated TLR4 complex
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: has_component PR:000025787 ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027191 ! interleukin-1 receptor-associated kinase 4 isoform 1 phosphorylated 1 (human)
relationship: has_component PR:000025786 ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:P58753-1 ! Toll/interleukin-1 receptor domain-containing adapter protein isoform 1 (human)
relationship: has_component PR:Q99836-1 ! myeloid differentiation primary response protein MyD88 isoform 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens