[Term]
id: PR:000027723
name: estrogen receptor isoform 1 phosphorylated 1
def: "An estrogen receptor isoform 1 that has been phosphorylated at the Ser residue within the most C-terminal CK-2 phosphorylation consensus sequence S-x(2)-[DE] in the N-terminal activation function 1 (AF1) domain (Pfam:PF02159). This is one of the major phosphorylation sites needed for activation of the receptor. Example: UniProtKB:P03372-1, Ser-167, MOD:00046." [PRO:PD, PMID:19940156, Pfam:PF02159]
comment: Category=modification.
synonym: "ESR1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027721 ! estrogen receptor isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine