[Term]
id: PR:000027830
name: cellular tumor antigen p53 isoform 1 phosphorylated 8
def: "A cellular tumor antigen p53 isoform 1 that has been phosphorylated at two Ser residues, one located in the DNA-binding domain and the other within the nuclear localization signal of the C-terminus of p53. Phosphorylation at Ser-215 hinders DNA binding and transactivation activity of p53. Example: UniProtKB:P04637-1, Ser-215/Ser-315, MOD:00046." [PRO:PD, PMID:15469940]
comment: Category=modification.
synonym: "TP53/iso:1/Phos:8" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000003036 ! cellular tumor antigen p53 isoform 1
relationship: has_part MOD:00046 ! O-phospho-L-serine