[Term]
id: PR:000028699
name: IRF3/IRF7:p-tbk1/p-IKKE:Ticam1:Ticam2:activated TLR4 complex
def: "A protein-containing complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), a phosphorylated kinase tbk1 or IKK epsilon and the non-phosphorylated form of IRF3 or IRF7. IRF3 and IRF7 are recruited via phosphorylated tbk1 and IKK epsilon." [PMID:14517278, PMID:14739303, PMID:16281057]
comment: Category=complex. Requested by=TLR. Original evidence source was Reactome entry REACT_27000.
is_a: GO:0032991 ! protein-containing complex