[Term]
id: PR:000028805
name: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2 (human)
def: "A phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2 in human. UniProtKB:P60484-1, Lys-125/Lys-128, MOD:00064." [PRO:PD, PMID:16829519]
comment: Category=organism-modification. Note: Acetylation inhibits PTEN ability to regulate PI3K/Akt pathway and modulates cell cycle progression. Acetylase=("KAT2B"; PR:000012332; Lys-125/Lys-128).
synonym: "hPTEN/iso:1/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P60484-1, Lys-125/Lys-128, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: PR:000028804 ! phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform 1 acetylated 2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine