[Term]
id: PR:000029188
name: cAMP-dependent protein kinase catalytic subunit
def: "A protein that has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069). Prototype members of this class are the catalytic subunit of PKA. Protein Kinase A (PKA) catalyzes the transfer of the terminal phosphate of ATP to Thr or Ser residues in a variety of protein substrates. The enzyme is composed of two subunit types: a catalytic subunit and a regulatory subunit. In the absence of cAMP, the two subunits are bound to each other and no catalysis can take place. In the presence of cAMP, the regulatory subunit binds cAMP, thus releasing the catalytic subunit." [PRO:CNA, PMID:20188216]
comment: Category=family.
synonym: "cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma" EXACT [PIRSF:PIRSF501114]
synonym: "PKA C" EXACT []
synonym: "PKA" RELATED []
xref: PIRSF:PIRSF501114
is_a: PR:000000001 ! protein