[Term]
id: PR:000035734
name: free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex (human)
def: "A free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex whose components are encoded in the genome of human." [Reactome:R-HSA-936954]
comment: Category=organism-complex. Requested by=TLR.
synonym: "activated TLR4:TRIF:K63-pUb-TRAF6:free K63-linked pUb:TAK1complex (human)" RELATED [Reactome:R-HSA-936954]
is_a: PR:000035733 ! free K63-linked pUb:TAK1complex:pUbtraf6:ticam1:ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000035732 {cardinality="2"} ! K63-polyubiquitin (human)
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:000035714 {cardinality="2"} ! TNF receptor-associated factor 6 K63-polyubiquitinated 1 (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000027103 {cardinality="2"} ! mitogen-activated protein kinase kinase kinase 7-interacting protein 2/3 (human)
relationship: has_component PR:Q15750 {cardinality="2"} ! TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: has_component PR:O43318 {cardinality="2"} ! mitogen-activated protein kinase kinase kinase 7 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens