[Term]
id: PR:000036035
name: IRF3:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex
def: "An IRF3/IRF7:p-tbk1/p-IKKE:Ticam1:Ticam2:activated TLR4 complex that is composed of activated Toll-like receptor 4 (TLR4), Ticam2 (TRAM), Ticam1 (TRIF), phosphorylated IKKE, and non-phosphorylated IRF3. IRF3 is recruited via phosphorylated IKKE." [PMID:14517278, PMID:14739303, PMID:16281057]
comment: Category=complex. Requested by=TLR. Original evidence source was Reactome entry REACT_27000.
is_a: PR:000028699 ! IRF3/IRF7:p-tbk1/p-IKKE:Ticam1:Ticam2:activated TLR4 complex