[Term]
id: PR:000036038
name: IRF7:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex (human)
def: "An IRF7:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex whose components are encoded in the genome of human." [PMID:14517278, PMID:14739303, PMID:16281057]
comment: Category=organism-complex. Requested by=TLR. Original evidence source was Reactome entry REACT_27000.
is_a: PR:000036037 ! IRF7:p-IKKE:K63polyUbiq-TRAF3:Ticam1:Ticam2:activated TLR4 complex
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000040891 {cardinality="2"} ! TIR domain-containing adapter molecule 2 isoform 1, initiator methionine removed myristoylated and phosphorylated 1 (human)
relationship: has_component PR:000036032 {cardinality="2"} ! TNF receptor-associated factor 3 K63-polyubiquitinated form (human)
relationship: has_component PR:000025787 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:000028691 {cardinality="2"} ! inhibitor of nuclear factor kappa-B kinase subunit epsilon phosphorylated 1 (human)
relationship: has_component PR:000028704 {cardinality="2"} ! interferon regulatory factor 7 unmodified form (human)
relationship: has_component PR:000025786 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (human)
relationship: has_component PR:Q8IUC6 {cardinality="2"} ! TIR domain-containing adapter molecule 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens