[Term]
id: PR:000036078
name: TIRAP:PIP2:activated TLR4 complex
def: "A protein-containing complex that is composed of TIRAP (MAL) bound to phosphatidyl inositol 4,5-bisphosphate in complex with the TLR4:MD2:LPS complex." [TLR:AMM, PMID:12447442]
comment: Category=complex. Requested by=TLR.
synonym: "Mal:activated TLR4 complex" EXACT []
synonym: "MAL:PIP2:LY96:LPS:TLR4" EXACT [PRO:DAN]
synonym: "MAL:PIP2:MD2:LPS:TLR4" EXACT []
is_a: GO:0032991 ! protein-containing complex
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: has_component CHEBI:16412 ! lipopolysaccharide
relationship: has_component PR:000026585 ! Toll-like receptor 4 isoform 1, signal peptide removed form
relationship: has_component PR:000001751 ! Toll/interleukin-1 receptor domain-containing adapter protein
relationship: has_component PR:000003298 ! lymphocyte antigen 96 isoform 1, signal peptide removed glycosylated form