[Term] id: PR:000036873 name: NS2B-NS3 polyprotein precursor def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3." [PRO:ES, PMID:10744671] comment: Category=modification. Requested by=IDODEN. Analysis of polyprotein processing in vivo established that the NS3 protease, as a heterodimeric complex with the viral activator protein NS2B, catalyzes the cis cleavage of NS2A-NS2B and NS2B-NS3, as well as the trans cleavage of NS3-NS4A and NS4B-NS5 sites in the polyprotein. [PMID:10744671, PRO:ES] synonym: "DenV-NS2B3" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: derives_from PR:000036838 ! NS12345 intersection_of: has_part PR:000036827 ! NS2B intersection_of: has_part PR:000036828 ! NS3 intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036826 ! NS2A-alpha intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5