[Term]
id: PR:000037477
name: TIRAP:PIP2:BTK:activated TLR4 complex (mouse)
def: "A TIRAP:PIP2:BTK:activated TLR4 complex in mouse that is composed of PI(4,5)P2, tyrosine unphosphorylated TIRAP/MAL, BTK, TLR4, MD2, and LPS." [TLR:AMM]
comment: Category=organism-complex. Evidence=(ECO:0000088, based on PR:000037447). Note: CD14 has not been added as part of the complex because there is not supporting evidence in mouse that CD14 is in the activated TLR4 complexes, beyond the initial trasnfer of LPS.
synonym: "MAL:PI(4,5)P2:BTK:activated TLR4 (mouse)" EXACT []
is_a: PR:000037472 ! TIRAP:PIP2:BTK:activated TLR4 complex
relationship: has_component CHEBI:18348 ! 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
relationship: has_component CHEBI:16412 {cardinality="2"} ! lipopolysaccharide
relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:Q99JY1 {cardinality="2"} ! Toll/interleukin-1 receptor domain-containing adapter protein (mouse)
relationship: has_component PR:P35991 {cardinality="2"} ! tyrosine-protein kinase BTK (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus