[Term]
id: PR:000037794
name: MD2:GB4:TLR4 complex (mouse)
def: "A protein-containing complex in mouse that is composed of two copies of the proteins Toll-like receptor 4 (TLR4) and the lymphocyte antigen 96 (LY96/MD2), and two globotetraosylceramide (GB4) molecules." [PRO:CNA, PMID:23471986]
comment: Category=organism-complex. Note: PMID:23471986, binding of Gb4 to the LPS receptor TLR4-MD-2 was demonstrated by coprecipitation of Gb4 with recombinant MD-2 and by native PAGE. Evidence=(ECO:0000269, based on PMID:23471986).
is_a: GO:0032991 ! protein-containing complex
relationship: has_component CHEBI:18259 {cardinality="2"} ! N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
relationship: has_component PR:000027172 {cardinality="2"} ! Toll-like receptor 4 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: has_component PR:000027171 {cardinality="2"} ! lymphocyte antigen 96 isoform 1, signal peptide removed N-glycosylated 1 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus