[Term]
id: PR:000044828
name: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial mature phosphorylated 3 (human)
def: "A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human) that has been phosphorylated on the residue at the position equivalent to Ser-300 of the amino acid sequence UniProtKB:P08559-1. Example: UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046." [PRO:AEL, PMID:11485553, PMID:19341700, PMID:7782287]
comment: Category=organism-modification. Kinase=("PDK1"; PR:Q15118; Ser-300). Kinase=("PDK2"; PR:Q15119; Ser-300). Kinase=("PDK3"; PR:Q15120; Ser-300). Kinase=("PDK4"; PR:Q16654; Ser-300). Evidence=(ECO:0000181, for phosphorylation). Evidence=(ECO:0000178, for phosphorylation). Evidence=(ECO:0000006, for phosphorylation). Evidence=(ECO:0000001, for cleavage based on PMID:23146587).
synonym: "hPDHA1/TransPep-/Phos:3" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P08559, 31-390, Ser-300, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "PRO_0000020440, Ser-300, MOD:00046" NARROW PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P08559-1, 31-390, Ser-300, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000044835 ! pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, transit peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens