[Term]
id: PR:000045378
name: cGMP-gated cation channel alpha-1 isoform 1 phosphorylated 2
def: "A cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Tyr residue within the VYSPGD motif located at the N terminus of the cyclic-nucleotide binding domain (CNDB) and the residue at the position equivalent to Tyr-503 of the amino acid sequence represented by UniProtKB:Q00194-1. This phosphorylation prevents Ca2+/CaM inhibition of the CNG channel, but at the same time has a similar effect, that is decreases the apparent affinity for cGMP. Example: UniProtKB:Q00194-1, Tyr-498/Tyr-503, MOD:00048." [PRO:CNA, PRO:DAN, PMID:23032687]
comment: Category=modification.
synonym: "CNGA1/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000932 ! cGMP-gated cation channel alpha-1 isoform 1 phosphorylated form
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine