[Term]
id: PR:000045489
name: interferon regulatory factor 3 isoform 1 phosphorylated 2 (human)
def: "An interferon regulatory factor 3 isoform 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-339 and on Ser and Thr residues within the 5ST site (Ser-396, Ser-398, Ser-402, Thr-404, and Ser-405). UniProtKB:Q14653-1, Ser-339/Ser-396/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047." [PRO:CNA, Reactome:R-HSA-936418]
comment: Category=organism-modification. Note: Reactome does not specify the precise isoform. However, it mentions that this proteoform is involved in dimerization. Based on the positions of the modified residues, and based on the position of the dimerization domain (203-385), only isoform 1 is eligible. [PRO:DAN, PMID:23824805]
synonym: "hIRF3/iso:1/Phos:2" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:Q14653-1, Ser-339/Ser-396/Ser-398/Ser-402/Ser-405, MOD:00046|Thr-404, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "p-5S,T404-IRF3 (human)" RELATED []
is_a: PR:Q14653-1 ! interferon regulatory factor 3 isoform 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens