[Term]
id: PR:000046372
name: serine/threonine-protein kinase A-Raf phosphorylated 2 (human)
def: "A serine/threonine-protein kinase A-Raf (human) that has been post-translationally modified to include phosphoserine at positions 299 and 582, phosphotyrosine at position 302, and phosphothreonine at positions 452 and 455 of the amino acid sequence represented by UniProtKB:P10398. UniProtKB:P10398, Ser-299/Ser-582, MOD:00046|Tyr-302, MOD:00048|Thr-452/Thr-455, MOD:00047." [PRO:DAN, Reactome:R-HSA-5672646, Reactome:R-HSA-5672648]
comment: Category=organism-modification. Note: The modified site indicated here (Ser-582) is referred to as Ser-576 in some manuscripts. [PRO:DAN, PMID:21779496]
synonym: "hARAF/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P10398, Ser-299/Ser-582, MOD:00046|Tyr-302, MOD:00048|Thr-452/Thr-455, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5672646 "PR:000046372 located_in GO:0005829"
xref: Reactome:R-HSA-5672648 "PR:000046372 located_in GO:0005886"
is_a: PR:P10398 ! serine/threonine-protein kinase A-Raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens