[Term]
id: PR:000046506
name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 2 (human)
def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 151, 446, 602, 729, and 750, and phosphothreonine at positions 401, 599 and 753 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047." [PRO:DAN, Reactome:R-HSA-5675199]
comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605]
synonym: "hBRAF/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000085665, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P15056, 2-766, Ser-151/Ser-446/Ser-602/Ser-729/Ser-750, MOD:00046|Thr-401/Thr-599/Thr-753, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5675199 "PR:000046506 located_in GO:0005886"
is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: lacks_part PR:000021937 ! initiator methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens