[Term]
id: PR:000046509
name: serine/threonine-protein kinase B-raf, initiator methionine removed phosphorylated 5 (human)
def: "A serine/threonine-protein kinase B-raf (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 446, 602 and 729, and phosphothreonine at position 599 of the amino acid sequence represented by UniProtKB:P15056. UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047." [PRO:DAN, Reactome:R-HSA-5672676, Reactome:R-HSA-5672679]
comment: Category=organism-modification. Note: A modified site indicated here (Ser-446) is referred to as Ser-445 in some manuscripts. [PRO:DAN, PMID:15710605]
synonym: "hBRAF/InitMet-/Phos:5" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000085665, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P15056, 2-766, Ser-446/Ser-602/Ser-729, MOD:00046|Thr-599, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-5672676 "PR:000046509 located_in GO:0005829"
xref: Reactome:R-HSA-5672679 "PR:000046509 located_in GO:0005886"
is_a: PR:P15056 ! serine/threonine-protein kinase B-raf (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: lacks_part PR:000021937 ! initiator methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens