[Term]
id: PR:000048294
name: dual specificity mitogen-activated protein kinase kinase 1, initiator methionine removed phosphorylated 3 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 218 and 222, and phosphothreonine at position 292 of the amino acid sequence represented by UniProtKB:Q02750. UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047." [PRO:DNx, Reactome:R-HSA-5674490]
comment: Category=organism-modification.
synonym: "hMAP2K1/InitMet-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000086365, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q02750, 2-393, Ser-218/Ser-222, MOD:00046|Thr-292, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5674490 "PR:000048294 located_in GO:0005829"
is_a: PR:Q02750 ! dual specificity mitogen-activated protein kinase kinase 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: lacks_part PR:000021937 ! initiator methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens