[Term]
id: PR:000048297
name: dual specificity mitogen-activated protein kinase kinase 3 phosphorylated 1 (human)
def: "A dual specificity mitogen-activated protein kinase kinase 3 (human) that has been phosphorylated on the residue at the position equivalent to Ser-218, and phosphothreonine at position 222 of the amino acid sequence represented by UniProtKB:P46734. UniProtKB:P46734, Ser-218, MOD:00046|Thr-222, MOD:00047." [PRO:DNx, Reactome:R-HSA-167955, Reactome:R-HSA-450229]
comment: Category=organism-modification. Note: The modified sites indicated here (Ser-218/Thr-222) are referred to as Ser-189/Thr-193 in some manuscripts. [PRO:DAN, PMID:8622669]
synonym: "hMAP2K3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P46734, Ser-218, MOD:00046|Thr-222, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN]
xref: Reactome:R-HSA-167955 "PR:000048297 located_in GO:0005829"
xref: Reactome:R-HSA-450229 "PR:000048297 located_in GO:0005654"
is_a: PR:P46734 ! dual specificity mitogen-activated protein kinase kinase 3 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens