[Term]
id: PR:000049509
name: DNA topoisomerase 1, initiator methionine removed sumoylated 1 (human)
def: "A DNA topoisomerase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include sumoylated lysine at position 117 of the amino acid sequence represented by UniProtKB:P11387. UniProtKB:P11387, 2-765, Lys-117, MOD:01149." [PRO:DNx, Reactome:R-HSA-4641364]
comment: Category=organism-modification.
synonym: "hTOP1/InitMet-/Sumo:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000145201, Lys-117, MOD:01149" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11387, 2-765, Lys-117, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4641364 "PR:000049509 located_in GO:0005654"
is_a: PR:P11387 ! DNA topoisomerase 1 (human)
relationship: has_part MOD:01149 ! sumoylated lysine
relationship: lacks_part PR:000021937 ! initiator methionine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens