[Term]
id: PR:000049845
name: TTK activation loop and P+1 loop phosphorylated form (human)
def: "A dual specificity protein kinase TTK (human) that has been phosphorylated on one of three sites within the activation loop and on a Thr residue in the P+1 loop. Example: UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047." [PRO:KER, PMID:19120698]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19120698). Kinase=("TTK"; PR:P33981; Thr-675). Kinase=("TTK"; PR:P33981; Thr-676). Kinase=("TTK"; PR:P33981; Ser-677). Kinase=("TTK"; PR:P33981; Thr-686).
synonym: "hTTK/(Act-loop_P+1-loop)Phos+" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P33981, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981, Ser-677, MOD:00046|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981, Thr-675, MOD:00047|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981, Thr-676, MOD:00047|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981-1, (Thr-675, MOD:00047 or Thr-676, MOD:00047 or Ser-677, MOD:00046)|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981-1, Ser-677, MOD:00046|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981-1, Thr-675, MOD:00047|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P33981-1, Thr-676, MOD:00047|Thr-686, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P33981 ! dual specificity protein kinase TTK (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens