[Term]
id: PR:000049849
name: epidermal growth factor receptor, signal peptide removed phosphorylated 3 (human)
def: "An epidermal growth factor receptor, signal peptide removed form (human) that has been phosphorylated on residues at positions equivalent to Ser-1070, Ser-1071, Ser-1081, and Ser-1166 of the amino acid sequence represented by UniProtKB:P00533-1. Example: UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046." [PRO:KER, PMID:10347170]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:10347170). Kinase=("CAMKII"; PR:000003197; Ser-1070/Ser-1071/Ser-1081/Ser-1166). Note: Ser-1166 is the major site of phosphorylation; this phosphorylation is involved in down-regulation of kinase activity.
synonym: "hEGFR/SigPep-/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P00533, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "UniProtKB:P00533-1, 25-1210, Ser-1070/Ser-1071/Ser-1081/Ser-1166, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:000028422 ! epidermal growth factor receptor, signal peptide removed form (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens