[Term]
id: PR:000050157
name: IgA1 immunoglobulin complex (human)
def: "An IgA immunoglobulin complex in human that is composed of (in monomeric form) two identical immunoglobulin heavy chains of the IgA1 isotype and two identical immunoglobulin light chains (kappa or lambda) held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA1 immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [PRO:ADD, PMID:16362985, GOC:add, ISBN:0781765196]
comment: Category=organism-complex. Requested by=HIPC. Requested by=CL. Note that an IgA1 immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "hIgA1" EXACT PRO-short-label [PRO:DAN]
synonym: "IgA antibody (human)" BROAD [PRO:ADD, GOC:add]
synonym: "IgA1 antibody (human)" NARROW [PRO:ADD, GOC:add]
is_a: GO:0071745 ! IgA immunoglobulin complex
relationship: has_component PR:000050179 {minCardinality="2"} ! IgA1 heavy chain protein (human)
relationship: has_component PR:000050183 {minCardinality="2"} ! immunoglobulin light chain protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens