[Term]
id: PR:000050284
name: RNA-directed RNA polymerase nsp12 (SARS-CoV-2)
def: "An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 4392-4393 and 5324-5325. UniProtKB:P0DTD1, 4393-5324." [PRO:DAN, GenPept:YP_009725307, UniProtKB:P0DTD1]
comment: Category=organism-modification. Note: 932 aa protein.
synonym: "ORF1ab/Clv:nsp12 (SARS2)" EXACT PRO-short-label [PRO:DAN]
synonym: "nsp12 (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "Pol (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "PRO_0000449629" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "RdRp (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "UniProtKB:P0DTD1, 4393-5324" EXACT PRO-proteoform-std [PRO:DAN]
xref: GenPept:YP_009725307
is_a: PR:000050283 ! ORF1ab proteolytic cleavage product (SARS-CoV-2)
relationship: only_in_taxon NCBITaxon:2697049 ! Severe acute respiratory syndrome coronavirus 2