[Term]
id: PR:000050287
name: uridylate-specific endoribonuclease nsp15 (SARS-CoV-2)
def: "An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 6452-6453 and 6798-6799. UniProtKB:P0DTD1, 6453-6798." [PRO:DAN, GenPept:YP_009725310, UniProtKB:P0DTD1]
comment: Category=organism-modification. Note: 346 aa protein.
synonym: "ORF1ab/Clv:nsp15 (SARS2)" EXACT PRO-short-label [PRO:DAN]
synonym: "endoRNAse (SARS-CoV-2)" EXACT [GenPept:YP_009725310]
synonym: "NendoU (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "nsp15 (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "PRO_0000449632" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "UniProtKB:P0DTD1, 6453-6798" EXACT PRO-proteoform-std [PRO:DAN]
xref: GenPept:YP_009725310
is_a: PR:000050283 ! ORF1ab proteolytic cleavage product (SARS-CoV-2)
relationship: only_in_taxon NCBITaxon:2697049 ! Severe acute respiratory syndrome coronavirus 2