[Term]
id: PR:000050469
name: hemoglobin A1c
def: "A hemoglobin complex that is composed of at least one beta-N-1-deoxy fructosyl hemoglobin subunit, in which the glycan is attached to the N-terminal valine (after initiator methionine removal) of one or both beta subunits." [PRO:DAN, PMID:16112961, PMID:9732983, Wikipedia:Glycated_hemoglobin]
comment: Category=complex. Note: The precise definition of hemoglobin A1c has evolved over time [https://medcraveonline.com/JNMR/laboratory-diagnosis-of-hba1c-a-review.html]. This PRO term is based on the most-precise definition currently in use.
synonym: "HbA1c" EXACT PRO-short-label [PRO:DAN]
synonym: "HgbA1c" EXACT [PMID:9732983]
synonym: "glycated hemoglobin" BROAD [PMID:9732983]
synonym: "glycohemoglobin" BROAD [PMID:9732983]
is_a: GO:0005833 ! hemoglobin complex
relationship: has_component CHEBI:30413 {cardinality="4"} ! heme
relationship: has_component PR:000020113 {cardinality="2"} ! hemoglobin subunit alpha, initiator methionine removed form
relationship: has_component PR:000050468 {maxCardinality="2"} ! hemoglobin subunit beta N-1-deoxyfructosylated 1
relationship: has_component PR:000050468 {minCardinality="1"} ! hemoglobin subunit beta N-1-deoxyfructosylated 1
relationship: has_component PR:000020114 {cardinality="2"} ! hemoglobin subunit beta, initiator methionine removed form