[Term]
id: PR:000060250
name: methemoglobin
def: "A hemoglobin complex in which the iron of the heme prosthetic group is in the ferric (Fe3+) state rather than the normal ferrous (Fe2+) state." [PRO:DAN, Wikipedia:Methemoglobin]
comment: Category=complex. Note: When normal hemoglobin carries oxygen, the iron(II) oxidizes to iron(III). In methemoglobin, the iron is in the iron(III) state in the absence of oxygen.
synonym: "metHb" EXACT PRO-short-label [PRO:DAN]
synonym: "ferric Hb" EXACT []
synonym: "ferrihaemoglobin" EXACT []
synonym: "ferrihemoglobin" EXACT []
xref: CHEBI:17423
is_a: GO:0005833 ! hemoglobin complex
relationship: non-covalently_bound_to CHEBI:26689 {cardinality="0"} ! singlet dioxygen
relationship: has_component CHEBI:38574 {cardinality="4"} ! ferriheme
relationship: has_component PR:000020113 {cardinality="2"} ! hemoglobin subunit alpha, initiator methionine removed form
relationship: has_component PR:000020114 {cardinality="2"} ! hemoglobin subunit beta, initiator methionine removed form