[Term]
id: PR:000060482
name: mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)
def: "A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]
comment: Category=organism-modification.
synonym: "hMAPK1/var:E322K/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-T185,Y187 MAPK1 E322K" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9652175]
synonym: "UniProtKB:P28482, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:29967" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P28482-1, 2-360, Thr-185/Tyr-187, MOD:00048|Glu-322, CHEBI:29967" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9652175 "PR:000060482 located_in GO:0005829"
is_a: PR:P28482 ! mitogen-activated protein kinase 1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens