[Term]
id: PR:000061072
name: receptor tyrosine-protein kinase erbB-2 sequence variant R896H, signal peptide removed phosphorylated 1 (human)
def: "A receptor tyrosine-protein kinase erbB-2 (human) that has a His residue at the position equivalent to Arg-896 of the amino acid sequence represented by UniProtKB:P04626-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Tyr-1023, Tyr-1139, Tyr-1196, Tyr-1221, Tyr-1222, and Tyr-1248. Example: UniProtKB:P04626-1, 23-1255, Arg-896, CHEBI:29979|Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048." [PRO:DNx, Reactome:R-HSA-9647217]
comment: Category=organism-modification.
synonym: "hERBB2/var:R896H/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "p-6Y-ERBB2 R896H" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-9647217]
synonym: "UniProtKB:P04626, 23-1255, Arg-896, CHEBI:29979|Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P04626-1, 23-1255, Arg-896, CHEBI:29979|Tyr-1023/Tyr-1139/Tyr-1196/Tyr-1221/Tyr-1222/Tyr-1248, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9647217 "PR:000061072 located_in GO:0005886"
is_a: PR:P04626 ! receptor tyrosine-protein kinase erbB-2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens