[Term]
id: PR:000061858
name: mothers against decapentaplegic homolog 3 ADP-ribosylated and phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 3 (human) that has been ADP-ribosylated on the residues at the positions equivalent to Glu-50 and Glu-52 and phosphorylated on the residues at the positions equivalent to Ser-423 and Ser-425 of the amino acid sequence represented by UniProtKB:P84022-1. Example: UniProtKB:P84022-1, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2187326]
comment: Category=organism-modification.
synonym: "hSMAD3/ADPribPhos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "2xADPRib-p-S423,S425-SMAD3" RELATED Reactome-displayName [PRO:DNx, Reactome:R-HSA-2187326]
synonym: "UniProtKB:P84022, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
synonym: "UniProtKB:P84022-1, Glu-50/Glu-52, MOD:00300|Ser-423/Ser-425, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2187326 "PR:000061858 located_in GO:0005654"
is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human)
relationship: has_part MOD:00300 ! L-glutamyl-5-poly(ADP-ribose)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens